The jaws and throats of most clamps don't allow much space for securing deeper on larger panels, boards or pieces. Sure, toggle clamps can be placed anywhere but you need to damage a surface in order to place them.
There are deep throat clamps. I found some that are 8 inches deep and that is good. But if you needed to clamp something that required a deeper throat it would not do.
I am picturing some sort of jig using boards to span from the edge of the work to the clamping location but I don't see that having enough downward pressure.
Forgive me if I lost you up until this point but for an extreme example: What if I wanted to clamp down a drill guide in the center of a 20 inch square board?