On all table saws I've seen rotate the wrench on the nut in the same direction that the blade turnsspins to loosen the nut (regardless of which way the arbor is mounted).
I can't imagine that it would be threaded the other way, because of safety, but who knows.
But like Matt mentions in a comment the manual will have the correct instructions.
Sometimes you have to give the wrench a few light taps if the nut has tightened up from the blade spinning.